The Development of a Versatile Trifunctional Scaffold for Biological Applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00445393" target="_blank" >RIV/61388963:_____/15:00445393 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/ejoc.201500255" target="_blank" >http://dx.doi.org/10.1002/ejoc.201500255</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejoc.201500255" target="_blank" >10.1002/ejoc.201500255</a>
Alternative languages
Result language
angličtina
Original language name
The Development of a Versatile Trifunctional Scaffold for Biological Applications
Original language description
We describe the synthesis of a trifunctional scaffold constructed from a planar core of trimesic acid derivatized with three propargylamine moieties. The scaffold was attached to a solid-phase resin through the carboxylic group of a fluorinated alkyl spacer arm. The orthogonal protection of two of the alkyne groups with triethylsilyl and triisopropylsilyl moieties enabled modular and efficient derivatization of the scaffold with three different azides by using solid-phase synthesis on amphiphilic ChemMatrix resin. We showed that a fluorine label can be used to quantify the content of fluorine-containing compounds by F-19 NMR spectroscopic analysis after cleavage from the resin. We have thus designed a versatile and convenient tool that could be usefulfor simple and rapid solid-phase syntheses of combinatorial libraries of the scaffold-based compounds, for example as new protein binders.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA14-17305S" target="_blank" >GA14-17305S: Insulin mimetics</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Organic Chemistry
ISSN
1434-193X
e-ISSN
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Volume of the periodical
2015
Issue of the periodical within the volume
17
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
3689-3701
UT code for WoS article
000355534600008
EID of the result in the Scopus database
2-s2.0-84934877597