Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00495687" target="_blank" >RIV/61388963:_____/18:00495687 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/ejoc.201800601" target="_blank" >http://dx.doi.org/10.1002/ejoc.201800601</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejoc.201800601" target="_blank" >10.1002/ejoc.201800601</a>
Alternative languages
Result language
angličtina
Original language name
Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides
Original language description
Multi-orthogonal scaffolds can be useful for the attachment of several different compounds to the same central skeleton. Such compounds can find applications in the development of protein mimics because of their potential to mimic several distant epitopes in the protein structure. Three new tri-orthogonal variants of a previously reported scaffold have been developed that are suitable for the solid-phase synthesis of three different peptides on the same skeleton. Different chemical moieties were combined for the phased attachment of amino acids to the scaffolds: Fmoc- or Alloc-protected amine, free or TIPS-protected alkyne or azido group. Several model compounds were prepared, characterized, and compared for their suitability as new scaffolds for peptide synthesis. All three scaffolds provided peptides with satisfactory yields and purities, making them suitable for a synthesis of libraries of compounds.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Organic Chemistry
ISSN
1434-193X
e-ISSN
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Volume of the periodical
2018
Issue of the periodical within the volume
37
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
5180-5192
UT code for WoS article
000446662900012
EID of the result in the Scopus database
2-s2.0-85050621783