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Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00495687" target="_blank" >RIV/61388963:_____/18:00495687 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1002/ejoc.201800601" target="_blank" >http://dx.doi.org/10.1002/ejoc.201800601</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/ejoc.201800601" target="_blank" >10.1002/ejoc.201800601</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides

  • Original language description

    Multi-orthogonal scaffolds can be useful for the attachment of several different compounds to the same central skeleton. Such compounds can find applications in the development of protein mimics because of their potential to mimic several distant epitopes in the protein structure. Three new tri-orthogonal variants of a previously reported scaffold have been developed that are suitable for the solid-phase synthesis of three different peptides on the same skeleton. Different chemical moieties were combined for the phased attachment of amino acids to the scaffolds: Fmoc- or Alloc-protected amine, free or TIPS-protected alkyne or azido group. Several model compounds were prepared, characterized, and compared for their suitability as new scaffolds for peptide synthesis. All three scaffolds provided peptides with satisfactory yields and purities, making them suitable for a synthesis of libraries of compounds.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10401 - Organic chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Journal of Organic Chemistry

  • ISSN

    1434-193X

  • e-ISSN

  • Volume of the periodical

    2018

  • Issue of the periodical within the volume

    37

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    13

  • Pages from-to

    5180-5192

  • UT code for WoS article

    000446662900012

  • EID of the result in the Scopus database

    2-s2.0-85050621783