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The high-resolution crystal structure of phosphatidylinositol 4-kinase II beta and the crystal structure of phosphatidylinositol 4-kinase II alpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00446387" target="_blank" >RIV/61388963:_____/15:00446387 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1107/S1399004715009505" target="_blank" >http://dx.doi.org/10.1107/S1399004715009505</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1107/S1399004715009505" target="_blank" >10.1107/S1399004715009505</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The high-resolution crystal structure of phosphatidylinositol 4-kinase II beta and the crystal structure of phosphatidylinositol 4-kinase II alpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design

  • Original language description

    Phosphatidylinositol 4-phosphate (PI4P) is the most abundant monophosphoinositide in eukaryotic cells. Humans have four phosphatidylinositol 4-kinases (PI4Ks) that synthesize PI4P, among which are PI4K II beta and PI4K II alpha. In this study, two crystal structures are presented: the structure of human PI4K II beta and the structure of PI4K II alpha containing a nucleoside analogue. The former, a complex with ATP, is the first high-resolution (1.9 angstrom) structure of a PI4K. These structures revealnew details such as high conformational heterogeneity of the lateral hydrophobic pocket of the C-lobe and together provide a structural basis for isoform-specific inhibitor design.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Acta Crystallographica Section D-Biological Crystalloghraphy

  • ISSN

    1399-0047

  • e-ISSN

  • Volume of the periodical

    71

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    DK - DENMARK

  • Number of pages

    9

  • Pages from-to

    1555-1563

  • UT code for WoS article

    000357829500014

  • EID of the result in the Scopus database

    2-s2.0-84937547552