The high-resolution crystal structure of phosphatidylinositol 4-kinase II beta and the crystal structure of phosphatidylinositol 4-kinase II alpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00446387" target="_blank" >RIV/61388963:_____/15:00446387 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1107/S1399004715009505" target="_blank" >http://dx.doi.org/10.1107/S1399004715009505</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1107/S1399004715009505" target="_blank" >10.1107/S1399004715009505</a>

Result language

angličtina

Original language name

The high-resolution crystal structure of phosphatidylinositol 4-kinase II beta and the crystal structure of phosphatidylinositol 4-kinase II alpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design

Original language description

Phosphatidylinositol 4-phosphate (PI4P) is the most abundant monophosphoinositide in eukaryotic cells. Humans have four phosphatidylinositol 4-kinases (PI4Ks) that synthesize PI4P, among which are PI4K II beta and PI4K II alpha. In this study, two crystal structures are presented: the structure of human PI4K II beta and the structure of PI4K II alpha containing a nucleoside analogue. The former, a complex with ATP, is the first high-resolution (1.9 angstrom) structure of a PI4K. These structures revealnew details such as high conformational heterogeneity of the lateral hydrophobic pocket of the C-lobe and together provide a structural basis for isoform-specific inhibitor design.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Crystallographica Section D-Biological Crystalloghraphy

ISSN

1399-0047

e-ISSN

—

Volume of the periodical

71

Issue of the periodical within the volume

7

Country of publishing house

DK - DENMARK

Number of pages

9

Pages from-to

1555-1563

UT code for WoS article

000357829500014

EID of the result in the Scopus database

2-s2.0-84937547552