Phosphatidylinositol 4-kinases: Function, structure, and inhibition
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00449209" target="_blank" >RIV/61388963:_____/15:00449209 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.yexcr.2015.03.028" target="_blank" >http://dx.doi.org/10.1016/j.yexcr.2015.03.028</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.yexcr.2015.03.028" target="_blank" >10.1016/j.yexcr.2015.03.028</a>
Alternative languages
Result language
angličtina
Original language name
Phosphatidylinositol 4-kinases: Function, structure, and inhibition
Original language description
The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking to and from the Golgi.Humans have two type II PI4Ks (alpha and beta) and two type III enzymes (alpha and beta). Recently, the crystal structures were solved for both type II and type III kinase revealing atomic details of their function. Importantly, the type III PI4Ks are hijacked by +RNA viruses to create so-called membranous web, an extensively phosphorylated and modified membrane system dedicated to their replication. Therefore, selective and potent inhibitors of PI4Ks have been developed as potential antiviral agents.Here we focus on the structure and function of PI4Ks and their potential in human medicine.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental Cell Research
ISSN
0014-4827
e-ISSN
—
Volume of the periodical
337
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
136-145
UT code for WoS article
000361160400003
EID of the result in the Scopus database
2-s2.0-84940845849