Straightforward Synthesis of Purine 4 '-Alkoxy-2 '-deoxynucleosides: First Report of Mixed Purine-Pyrimidine 4 '-Alkoxyoligodeoxynucleotides as New RNA Mimics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00446565" target="_blank" >RIV/61388963:_____/15:00446565 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/acs.orglett.5b01430" target="_blank" >http://dx.doi.org/10.1021/acs.orglett.5b01430</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.orglett.5b01430" target="_blank" >10.1021/acs.orglett.5b01430</a>
Alternative languages
Result language
angličtina
Original language name
Straightforward Synthesis of Purine 4 '-Alkoxy-2 '-deoxynucleosides: First Report of Mixed Purine-Pyrimidine 4 '-Alkoxyoligodeoxynucleotides as New RNA Mimics
Original language description
Purine and pyrimidine 4'-alkoxy-2'-deoxymicleosides were efficiently prepared from nucleoside 4'-5'-enol acetates in three steps by N-iodosuccinimide promoted alkoxylation, hydrolysis, and reduction followed by conversion to phosphoramidite monomers forthe solid-phase synthesis of the oligonucleotides. Fully modified 4'-alkoxyoligodeoxynucleotides, which are characterized by a prevalent N-type (RNA-like) conformation, exhibited superior chemical and nuclease resistance as well as excellent hybridization properties with a strong tendency for RNA-selective hybridization, suggesting a potential application of 4'-alkoxy-oligodeoxynucleotides in antigense technologies.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Organic Letters
ISSN
1523-7060
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
14
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
3426-3429
UT code for WoS article
000358395500013
EID of the result in the Scopus database
2-s2.0-84937571546