A Study of the Reactivity of Polyhydroxylated Sterol Derivatives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00447754" target="_blank" >RIV/61388963:_____/15:00447754 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/ajoc.201500138" target="_blank" >http://dx.doi.org/10.1002/ajoc.201500138</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ajoc.201500138" target="_blank" >10.1002/ajoc.201500138</a>
Alternative languages
Result language
angličtina
Original language name
A Study of the Reactivity of Polyhydroxylated Sterol Derivatives
Original language description
A detailed study of regiospecific silylation, oxidation, and reduction of sterols is reported. The different reactivity of 2 alpha and 3 alpha hydroxy groups is demonstrated on a 2 alpha,3 alpha-dihydroxy-5 alpha-pregnane-6,20-dione as a model substrate.A regiospecific silylation of the 2 alpha-alcohol occurred when silyl chloride was used under mild reaction conditions. The selective oxidation of one of the 2 alpha,3 alpha-diols by dimethyldioxirane or the Dess-Martin periodinane led to a mixture of alpha-hydroxyketones with high prevalence of 3,6,20-trione over 2,6,20-trione in the ratio 10:1. A regiospecific reduction of a model substrate by lithium tri-tert-butoxyaluminium hydride gives the C6 alcohol.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/IAA400550801" target="_blank" >IAA400550801: Synthesis of tritium labelled brassinosteroids and their application in the studies of their mechanism of action on molecular level.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Asian Journal of Organic Chemistry
ISSN
2193-5807
e-ISSN
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Volume of the periodical
4
Issue of the periodical within the volume
8
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
808-817
UT code for WoS article
000359426800016
EID of the result in the Scopus database
2-s2.0-84938750699