1,2,4-Triazole-based N-heterocyclic carbene complexes of gold(I): synthesis, characterization and biological activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F16%3A00460187" target="_blank" >RIV/61388963:_____/16:00460187 - isvavai.cz</a>
Alternative codes found
RIV/00216275:25310/16:39901641
Result on the web
<a href="http://dx.doi.org/10.1002/aoc.3434" target="_blank" >http://dx.doi.org/10.1002/aoc.3434</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/aoc.3434" target="_blank" >10.1002/aoc.3434</a>
Alternative languages
Result language
angličtina
Original language name
1,2,4-Triazole-based N-heterocyclic carbene complexes of gold(I): synthesis, characterization and biological activity
Original language description
Two gold(I) complexes of the (NHC)AuX type bearing a triazole-based N-heterocyclic carbene (NHC) ligand (1-tert-butyl-4-(4-methylphenyl)-3-phenyl-1H-1,2,4-triazol-4-ium-5-ylidene) and various halide ligands (X = Br, I) were synthesized and characterized in solution using NMR spectroscopy as well as in the solid state using X-ray diffraction techniques. The cytotoxic properties of both compounds and the precursor, (NHC)AuCl, were screened against a panel of human tumour cell lines including liver cancer (HepG2), cervical cancer (HeLa S3) and leukaemia (CCRF-CEM, HL-60) and compared to cisplatin and auranofin. It was found that the activities of the chloro and bromo derivatives were generally superior to that of cisplatin and slightly less effective compared to auranofin, except for HepG2 cells where auranofin was not as effective. In addition, the ability to induce membrane phosphatidyl serine externalization as a hallmark of apoptosis in CCRF-CEM leukaemic cells was investigated.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Applied Organometallic Chemistry
ISSN
0268-2605
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
318-322
UT code for WoS article
000374761400010
EID of the result in the Scopus database
2-s2.0-84957673427