Stearylated cycloarginine nanosystems for intracellular delivery - simulations, formulation and proof of concept

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F16%3A00469474" target="_blank" >RIV/61388963:_____/16:00469474 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1039/c6ra16432c" target="_blank" >http://dx.doi.org/10.1039/c6ra16432c</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c6ra16432c" target="_blank" >10.1039/c6ra16432c</a>

Result language

angličtina

Original language name

Stearylated cycloarginine nanosystems for intracellular delivery - simulations, formulation and proof of concept

Original language description

Cationization of nanocarriers has been sought after as a viable strategy to surmount cellular barriers that impede intracellular drug and gene delivery. A plethora of cationic compounds including both lipids and polymers have been designed and developed for efficient cellular penetration. The toxicity of these cationic agents, however, precludes their use in drug delivery. Conjugation with biomolecules like sugars and amino acids to produce novel cationic agents is being investigated to generate biocompatible molecules to achieve safe drug delivery. In this study, we propose to mitigate the toxicity of stearylamine, a cationic lipid, by tethering it to arginine, to yield a novel cationic ligand. Ligand loaded liposomes and nanoparticles were fabricated and evaluated for their surface charge and cellular uptake. Furthermore, molecular dynamics simulations were utilized as a tool to understand the accessibility of the novel ligand and stearylamine loaded liposomal systems. This paper presents the one pot synthesis of a novel stearylated arginine dipeptide and its incorporation in delivery systems along with its in vitro and in vivo toxicity evaluation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

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Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

RSC Advances

ISSN

2046-2069

e-ISSN

—

Volume of the periodical

6

Issue of the periodical within the volume

114

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

113538-113550

UT code for WoS article

000389905300093

EID of the result in the Scopus database

2-s2.0-85002427129