Helquat derivatives, preparation thereof, and use thereof as medicaments
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F16%3A00471681" target="_blank" >RIV/61388963:_____/16:00471681 - isvavai.cz</a>
Result on the web
<a href="https://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=9340543B2&KC=B2&FT=D&ND=4&date=20160517&DB=&locale=en_EP" target="_blank" >https://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=9340543B2&KC=B2&FT=D&ND=4&date=20160517&DB=&locale=en_EP</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Helquat derivatives, preparation thereof, and use thereof as medicaments
Original language description
The invention provides helquat derivatives of general formula I, wherein substituents R1 and R2 are independently selected from a group comprising H and C1 to C3 alkyl; up to three of S1,2, S1',2', S3,4 and S3', 4' are present, each of S1,2, S1',2', S3,4 and S3',4' independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms; one or two atoms selected from the carbon atoms with the descriptor 2, 4, 2', and 4' are substituted with a substituent R3 of general formula II or general formula III wherein R4 is substituted or unsubstituted aryl; T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms; and anions (X1)- and (X2)- independently represent anions of pharmaceutically acceptable salts. The helquat derivatives are useful as medicaments in the treatment of diseases related to increased cellular proliferation, such as oncologic diseases.
Czech name
—
Czech description
—
Classification
Type
P - Patent
CEP classification
CC - Organic chemistry
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Patent/design ID
US9340543
Publisher
US001 -
Publisher name
United States Patent and Trademark Office (USPTO)
Place of publication
Alexandria
Publication country
US - UNITED STATES
Date of acceptance
May 17, 2016
Owner name
Ústav organické chemie a biochemie AV ČR, v. v. i
Method of use
A - Výsledek využívá pouze poskytovatel
Usage type
A - K využití výsledku jiným subjektem je vždy nutné nabytí licence