Helquat derivatives, preparation thereof, and use thereof as medicaments

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00484671" target="_blank" >RIV/61388963:_____/17:00484671 - isvavai.cz</a>
Result on the web
<a href="https://worldwide.espacenet.com/publicationDetails/biblio?CC=EP&NR=2945937B1&KC=B1&FT=D&ND=4&date=20170222&DB=&locale=en_EP#" target="_blank" >https://worldwide.espacenet.com/publicationDetails/biblio?CC=EP&NR=2945937B1&KC=B1&FT=D&ND=4&date=20170222&DB=&locale=en_EP#</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Helquat derivatives, preparation thereof, and use thereof as medicaments
Original language description
The invention provides helquat derivatives of general formula I, wherein substituents R1 and R2 are independently selected from a group comprising H and C1 to C3 alkyl, up to three of S1,2, S1',2', S3,4 and S3',4' are present, each of S1,2, S1',2', S3,4 and S3',4' independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms, one or two atoms selected from the carbon atoms with the descriptor 2, 4, 2', and 4' are substituted with a substituent R3 of general formula (II) or general formula (III) wherein R4 is substituted or unsubstituted aryl, T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms, and anions (X1)- and (X2)- independently represent anions of pharmaceutically acceptable salts. The helquat derivatives are useful as medicaments in the treatment of diseases related to increased cellular proliferation, such as oncologic diseases.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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