Cholesterol oxidation products and their biological importance
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F16%3A00472250" target="_blank" >RIV/61388963:_____/16:00472250 - isvavai.cz</a>
Alternative codes found
RIV/61388955:_____/16:00468638
Result on the web
<a href="http://dx.doi.org/10.1016/j.chemphyslip.2016.03.001" target="_blank" >http://dx.doi.org/10.1016/j.chemphyslip.2016.03.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.chemphyslip.2016.03.001" target="_blank" >10.1016/j.chemphyslip.2016.03.001</a>
Alternative languages
Result language
angličtina
Original language name
Cholesterol oxidation products and their biological importance
Original language description
The main biological cause of oxysterols is the oxidation of cholesterol. They differ from cholesterol by the presence of additional polar groups that are typically hydroxyl, keto, hydroperoxy, epoxy, or carboxyl moieties. Under typical conditions, oxysterol concentration is maintained at a very low and precisely regulated level, with an excess of cholesterol. Like cholesterol, many oxysterols are hydrophobic and hence confined to cell membranes. However, small chemical differences between the sterols can significantly affect how they interact with other membrane components, and this in turn can have a substantial effect on membrane properties. In this spirit, this review describes the biological importance and the roles of oxysterols in the human body. We focus primarily on the effect of oxysterols on lipid membranes, but we also consider other issues such as enzymatic and nonenzymatic synthesis processes of oxysterols as well as pathological conditions induced by oxysterols.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemistry and Physics of Lipids
ISSN
0009-3084
e-ISSN
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Volume of the periodical
199
Issue of the periodical within the volume
Sep
Country of publishing house
IE - IRELAND
Number of pages
17
Pages from-to
144-160
UT code for WoS article
000381833800014
EID of the result in the Scopus database
2-s2.0-84959894259