The role of oxysterols in human cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F17%3A00011769" target="_blank" >RIV/75010330:_____/17:00011769 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/17:43913216 RIV/00216208:11140/17:10337661
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1043276017300383?via%3Dihub" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1043276017300383?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tem.2017.03.002" target="_blank" >10.1016/j.tem.2017.03.002</a>
Alternative languages
Result language
angličtina
Original language name
The role of oxysterols in human cancer
Original language description
Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested in the diet. By modulating the activity of many proteins [e.g., liver X receptors (LXRs), oxysterol-binding proteins (OSBPs), some ATP-binding cassette (ABC) transporters], oxysterols can affect many cellular functions and influence various physiological processes (e.g., cholesterol metabolism, membrane fluidity regulation, intracellular signaling pathways). Therefore, the role of oxysterols is also important in pathological conditions (e.g., atherosclerosis, diabetes mellitus type 2, neurodegenerative disorders). Finally, current evidence suggests that oxysterols play a role in malignancies such as breast, prostate, colon, and bile duct cancer. This review summarizes the physiological importance of oxysterols in the human body with a special emphasis on their roles in various tumors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30101 - Human genetics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Trends in Endocrinology and Metabolism
ISSN
1043-2760
e-ISSN
1879-3061
Volume of the periodical
28
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
485-496
UT code for WoS article
000403204400002
EID of the result in the Scopus database
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