Ubiquitination and proteasome-mediated degradation of voltage-gated Ca2+ channels and potential pathophysiological implications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00474256" target="_blank" >RIV/61388963:_____/17:00474256 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.4149/gpb_2016037" target="_blank" >http://dx.doi.org/10.4149/gpb_2016037</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/gpb_2016037" target="_blank" >10.4149/gpb_2016037</a>

Result language

angličtina

Original language name

Ubiquitination and proteasome-mediated degradation of voltage-gated Ca2+ channels and potential pathophysiological implications

Original language description

Recent findings have revealed a fundamental role of the ubiquitin-proteasome system (UPS) in the regulation of voltage-gated Ca2+ channels (VGCCs). It has been proposed that the ubiquitination-deubiquitination balance dictates the number of channels expressed at the plasma membrane, which in turn influences a number of physiological and pathophysiological processes. This minireview surveys recent studies showing that VGCCs may be ubiquitinated in an unexpectedly complex manner, and highlights the role of the UPS in the regulation of the channels, focusing on the mechanisms that control their cell surface expression. The exciting new findings in this emerging field suggest that the turnover of VGCCs may be determined to a large degree by the activity of the UPS, and that alteration of the UPS molecular machinery may be one of the underlying mechanisms occurring in a number of channelopathies.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

General Physiology and Biophysics

ISSN

0231-5882

e-ISSN

—

Volume of the periodical

36

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

5

Pages from-to

1-5

UT code for WoS article

000392164100001

EID of the result in the Scopus database

2-s2.0-85021857536