Cholesteryl esters of omega-(O-acyl)-hydroxy fatty acids in vernix caseosa
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00478141" target="_blank" >RIV/61388963:_____/17:00478141 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/17:10364232 RIV/00216208:11310/17:10364232 RIV/00064165:_____/17:10364232
Result on the web
<a href="http://dx.doi.org/10.1194/jlr.M075333" target="_blank" >http://dx.doi.org/10.1194/jlr.M075333</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1194/jlr.M075333" target="_blank" >10.1194/jlr.M075333</a>
Alternative languages
Result language
angličtina
Original language name
Cholesteryl esters of omega-(O-acyl)-hydroxy fatty acids in vernix caseosa
Original language description
Cholesteryl esters of omega-(O-acyl)-hydroxy FAs (Chl. OAHFAs) were identified for the first time in vernix caseosa and characterized using chromatography and MS. Chl-omega OAHFAs were isolated using adsorption chromatography on silica gel and magnesium hydroxide. Their general structure was established using high-resolution and tandem MS of intact lipids, and products of their transesterification and derivatizations. Individual molecular species were characterized using nonaqueous reversed-phase HPLC coupled to atmospheric pressure chemical ionization. The analytes were detected as protonated molecules, and their structures were elucidated in the negative ion mode using controlled thermal decomposition and data-dependent fragmentation. About three hundred molecular species of Chl-omega OAHFAs were identified in this way. The most abundant Chl. OAHFAs contained 32:1 omega-hydroxy FA (omega-HFA) and 14:0, 15:0, 16:0, 16:1, and 18:1 FAs. The double bond in the 32:1 omega-HFA was in the n-7 and n-9 positions. Chl-omega OAHFAs are estimated to account for approximately 1-2% of vernix caseosa lipids.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/GAP206%2F12%2F0750" target="_blank" >GAP206/12/0750: Lipidome of vernix caseosa: comprehensive analysis and biological variability</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Lipid Research
ISSN
0022-2275
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
1579-1590
UT code for WoS article
000406686600009
EID of the result in the Scopus database
2-s2.0-85026740185