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The identification of new substrates of human DHRS7 by molecular modeling and in vitro testing

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00483295" target="_blank" >RIV/61388963:_____/17:00483295 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11160/17:10365305

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.ijbiomac.2017.07.012" target="_blank" >http://dx.doi.org/10.1016/j.ijbiomac.2017.07.012</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ijbiomac.2017.07.012" target="_blank" >10.1016/j.ijbiomac.2017.07.012</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The identification of new substrates of human DHRS7 by molecular modeling and in vitro testing

  • Original language description

    Human DHRS7 (SDR34C1) is one of insufficiently described enzymes of the short-chain dehydrogenase/reductase superfamily. The members of this superfamily often play an important pato/physiological role in the human body, participating in the metabolism of diverse substrates (e.g. retinoids, steroids, xenobiotics). A systematic approach to the identification of novel, physiological substrates of DHRS7 based on a combination of homology modeling, structure-based virtual screening and experimental evaluation has been used. Three novel substrates of DHRS7 (dihydrotestosterone, benzil and 4,4'-dimetylbenzil) have been described.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/LM2015047" target="_blank" >LM2015047: Czech National Infrastructure for Biological Data</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Biological Macromolecules

  • ISSN

    0141-8130

  • e-ISSN

  • Volume of the periodical

    105

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    12

  • Pages from-to

    171-182

  • UT code for WoS article

    000414882900019

  • EID of the result in the Scopus database

    2-s2.0-85023594559