The identification of new substrates of human DHRS7 by molecular modeling and in vitro testing

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00483295" target="_blank" >RIV/61388963:_____/17:00483295 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/17:10365305
Result on the web
<a href="http://dx.doi.org/10.1016/j.ijbiomac.2017.07.012" target="_blank" >http://dx.doi.org/10.1016/j.ijbiomac.2017.07.012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijbiomac.2017.07.012" target="_blank" >10.1016/j.ijbiomac.2017.07.012</a>

Result language
angličtina
Original language name
The identification of new substrates of human DHRS7 by molecular modeling and in vitro testing
Original language description
Human DHRS7 (SDR34C1) is one of insufficiently described enzymes of the short-chain dehydrogenase/reductase superfamily. The members of this superfamily often play an important pato/physiological role in the human body, participating in the metabolism of diverse substrates (e.g. retinoids, steroids, xenobiotics). A systematic approach to the identification of novel, physiological substrates of DHRS7 based on a combination of homology modeling, structure-based virtual screening and experimental evaluation has been used. Three novel substrates of DHRS7 (dihydrotestosterone, benzil and 4,4'-dimetylbenzil) have been described.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/LM2015047" target="_blank" >LM2015047: Czech National Infrastructure for Biological Data</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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