Importance of ABCC1 for cancer therapy and prognosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10281236" target="_blank" >RIV/00216208:11140/14:10281236 - isvavai.cz</a>
Alternative codes found
RIV/75010330:_____/14:00010632 RIV/00216208:11120/14:43909221
Result on the web
<a href="http://dx.doi.org/10.3109/03602532.2014.901348" target="_blank" >http://dx.doi.org/10.3109/03602532.2014.901348</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/03602532.2014.901348" target="_blank" >10.3109/03602532.2014.901348</a>
Alternative languages
Result language
angličtina
Original language name
Importance of ABCC1 for cancer therapy and prognosis
Original language description
Multidrug resistance presents one of the most important causes of cancer treatment failure. Numerous in vitro and in vivo data have made it clear that multidrug resistance is frequently caused by enhanced expression of ATP-binding cassette (ABC) transporters. ABC transporters are membrane-bound proteins involved in cellular defense mechanisms, namely, in outward transport of xenobiotics and physiological substrates. Their function thus prevents toxicity as carcinogenesis on one hand but may contribute to the resistance of tumor cells to a number of drugs including chemotherapeutics on the other. Within 48 members of the human ABC superfamily there are several multidrug resistance-associated transporters. Due to the well documented susceptibility of numerous drugs to efflux via ABC transporters it is highly desirable to assess the status of ABC transporters for individualization of treatment by their substrates. The multidrug resistance associated protein 1 (MRP1) encoded by ABCC1 gene
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Drug Metabolism Reviews
ISSN
0360-2532
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
325-342
UT code for WoS article
000340454100005
EID of the result in the Scopus database
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