Optically Active Vibrational Spectroscopy of alpha-Aminoisobutyric Acid Foldamers in Organic Solvents and Phospholipid Bilayers

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00491856" target="_blank" >RIV/61388963:_____/18:00491856 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/chem.201801121" target="_blank" >http://dx.doi.org/10.1002/chem.201801121</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/chem.201801121" target="_blank" >10.1002/chem.201801121</a>

Result language
angličtina
Original language name
Optically Active Vibrational Spectroscopy of alpha-Aminoisobutyric Acid Foldamers in Organic Solvents and Phospholipid Bilayers
Original language description
Helical alpha-aminoisobutyric acid (Aib) foldamers show great potential as devices for the communication of conformational information across phospholipid bilayers, but determining their conformation in bilayers remains a challenge. In the present study, Raman, Raman optical activity (ROA), infrared (IR) and vibrational circular dichroism (VCD) spectroscopies have been used to analyze the conformational preferences of Aib foldamers in solution and when interacting with bilayers. A 3(10)-helix marker band at 1665-1668 cm(-1) in Raman spectra was used to show that net helical content increased strongly with oligomer length. ROA and VCD spectra of chiral Aib foldamers provided the chiroptical signature for both left- and right-handed 3(10)-helices in organic solvents, with VCD establishing that foldamer screw-sense was preserved when the foldamers became embedded within bilayers. However, the population distribution between different secondary structures was perturbed by the chiral phospholipid. These studies indicate that ROA and VCD spectroscopies are valuable tools for the study of biomimetic structures, such as artificial signal transduction molecules, in phospholipid bilayers.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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