Optical tools for understanding the complexity of beta-cell signalling and insulin release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00498654" target="_blank" >RIV/61388963:_____/18:00498654 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/s41574-018-0105-2" target="_blank" >http://dx.doi.org/10.1038/s41574-018-0105-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41574-018-0105-2" target="_blank" >10.1038/s41574-018-0105-2</a>
Alternative languages
Result language
angličtina
Original language name
Optical tools for understanding the complexity of beta-cell signalling and insulin release
Original language description
Following stimulation, pancreatic beta-cells must orchestrate a plethora of signalling events to ensure the appropriate release of insulin and maintenance of normal glucose homeostasis. Failure at any point in this cascade leads to impaired insulin secretion, elevated blood levels of glucose and eventually type 2 diabetes mellitus. Likewise, beta-cell replacement or regeneration strategies for the treatment of both type 1 and type 2 diabetes mellitus might fail if the correct cell signalling phenotype cannot be faithfully recreated. However, current understanding of beta-cell function is complicated because of the highly dynamic nature of their intracellular and intercellular signalling as well as insulin release itself. beta-Cells must precisely integrate multiple signals stemming from multiple cues, often with differing intensities, frequencies and cellular and subcellular localizations, before converging these signals onto insulin exocytosis. In this respect, optical approaches with high resolution in space and time are extremely useful for properly deciphering the complexity of beta-cell signalling. An increased understanding of beta-cell signalling might identify new mechanisms underlying insulin release, with relevance for future drug therapy and de novo stem cell engineering of functional islets.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Reviews Endocrinology
ISSN
1759-5029
e-ISSN
—
Volume of the periodical
14
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
17
Pages from-to
721-737
UT code for WoS article
000449832300014
EID of the result in the Scopus database
2-s2.0-85055429349