An Extended Approach for the Development of Fluorogenic trans-Cyclooctene-Tetrazine Cycloadditions

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00504249" target="_blank" >RIV/61388963:_____/19:00504249 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/cbic.201800711" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/cbic.201800711</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cbic.201800711" target="_blank" >10.1002/cbic.201800711</a>

Result language
angličtina
Original language name
An Extended Approach for the Development of Fluorogenic trans-Cyclooctene-Tetrazine Cycloadditions
Original language description
Inverse-electron-demand Diels-Alder (iEDDA) cycloaddition between 1,2,4,5-tetrazines and strained dienophiles belongs among the most popular bioconjugation reactions. In addition to its fast kinetics, this cycloaddition can be tailored to produce fluorescent products from non-fluorescent starting materials. Here we show that even the reaction intermediates formed in iEDDA cycloaddition can lead to the formation of new types of fluorophores. The influence of various substituents on their photophysical properties and the generality of the approach with use of various trans-cyclooctene derivatives were studied. Model bioimaging experiments demonstrate the application potential of fluorogenic iEDDA cycloaddition.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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