Rapid diffusion of cholesterol along polyunsaturated membranes via deep dives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00507305" target="_blank" >RIV/61388963:_____/19:00507305 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2019/CP/C9CP02022E#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2019/CP/C9CP02022E#!divAbstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c9cp02022e" target="_blank" >10.1039/c9cp02022e</a>

Result language
angličtina
Original language name
Rapid diffusion of cholesterol along polyunsaturated membranes via deep dives
Original language description
Cholesterol regulates the function of membrane proteins either via direct or membrane-mediated effects. Therefore, its ready availability is crucial for many protein-governed cellular processes. Recent studies suggest that cholesterol can partition to the core of polyunsaturated membranes, where cholesterol binding sites of many membrane proteins are also located. This core region is characterized by a lower viscosity. Therefore, we hypothesized that cholesterol partitioning into the membrane interior increases the rate of its diffusion in polyunsaturated membrane environments. We studied the behavior of cholesterol in membranes with increasing level of lipid chain unsaturation using a combination of atomistic and coarse-grained molecular dynamics simulations. Our simulations suggest a strong correlation between entropy-driven enhanced cholesterol partitioning to the membrane core and its faster lateral diffusion, which indicates that the less viscous membrane core indeed provides an efficient means for cholesterol movement in polyunsaturated membrane environments.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry

Project
<a href="/en/project/GX19-26854X" target="_blank" >GX19-26854X: Concert of lipids, ions, and proteins in cell membrane dynamics and function</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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