Synthesis of potent neuroprotective butenolides based on plant smoke derived 3,4,5-Trimethylfuran-2(5H)-one and 3-methyl-2H-furo[2,3-c]pyrone-2-one
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00507770" target="_blank" >RIV/61388963:_____/19:00507770 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0031942218307982?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0031942218307982?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.phytochem.2019.03.014" target="_blank" >10.1016/j.phytochem.2019.03.014</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis of potent neuroprotective butenolides based on plant smoke derived 3,4,5-Trimethylfuran-2(5H)-one and 3-methyl-2H-furo[2,3-c]pyrone-2-one
Original language description
Smoke derived karrikinolide and trimethylbutenolide exerted neuroprotective effects against monoamine oxidase and acetylcholinesterase. Synthesis of potent analogs was achieved. Sulphur substitution in the bicyclic ring structure of KAR(1) displayed the most encouraging activity returning IC50 values of 13.75 +/- 0.001 mu M and 0.03 +/- 0.02 mu M for monoamine oxidase A and B and 0.08 +/- 0.006 mu M for acetylcholinesterase. Neuroprotective butenolides may be particularly useful in the treatment of depressive disorders, Alzheimer's and Parkinson's diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Phytochemistry
ISSN
0031-9422
e-ISSN
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Volume of the periodical
163
Issue of the periodical within the volume
Jul
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
187-194
UT code for WoS article
000474327100018
EID of the result in the Scopus database
2-s2.0-85067246936