GTP-Dependent Formation of Multimeric G-Quadruplexes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00508593" target="_blank" >RIV/61388963:_____/19:00508593 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/19:10409347

Result on the web

<a href="https://pubs.acs.org/doi/10.1021/acschembio.9b00428" target="_blank" >https://pubs.acs.org/doi/10.1021/acschembio.9b00428</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acschembio.9b00428" target="_blank" >10.1021/acschembio.9b00428</a>

Result language

angličtina

Original language name

GTP-Dependent Formation of Multimeric G-Quadruplexes

Original language description

G-Quadruplexes are noncanonical nucleic acid structures made up of stacked guanosine tetrads connected by short loops. They are frequently used building blocks in synthetic biology and thought to play widespread biological roles. Multimerization can change the functional properties of G-quadruplexes, and understanding the factors that modulate this process remains an important goal. Here, we report the discovery of a novel mechanism by which the formation of multimeric G-quadruplexes can be controlled using GTP. We show that GTP likely inhibits multimer formation by becoming incorporated into a tetrad in the monomeric form of the structure and define the sequence requirements of G-quadruplexes that form GTP-dependent structures. These experiments provide new insights into the small molecule control of G-quadruplex multimerization. They also suggest possible roles for GTP-dependent multimeric G-quadruplexes in both synthetic and natural biological systems.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/EF16_019%2F0000729" target="_blank" >EF16_019/0000729: Chemical biology for drugging undruggable targets</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS Chemical Biology

ISSN

1554-8929

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

1951-1963

UT code for WoS article

000487577000012

EID of the result in the Scopus database

2-s2.0-85072509326