Structure and Function of Multimeric G-Quadruplexes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00508830" target="_blank" >RIV/61388963:_____/19:00508830 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/1420-3049/24/17/3074" target="_blank" >https://www.mdpi.com/1420-3049/24/17/3074</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules24173074" target="_blank" >10.3390/molecules24173074</a>

Result language

angličtina

Original language name

Structure and Function of Multimeric G-Quadruplexes

Original language description

G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine tetrads. They are frequently used as building blocks and functional elements in fields such as synthetic biology and also thought to play widespread biological roles. G-quadruplexes are often studied as monomers, but can also form a variety of higher-order structures. This increases the structural and functional diversity of G-quadruplexes, and recent evidence suggests that it could also be biologically important. In this review, we describe the types of multimeric topologies adopted by G-quadruplexes and highlight what is known about their sequence requirements. We also summarize the limited information available about potential biological roles of multimeric G-quadruplexes and suggest new approaches that could facilitate future studies of these structures.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/EF16_019%2F0000729" target="_blank" >EF16_019/0000729: Chemical biology for drugging undruggable targets</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecules

ISSN

1420-3049

e-ISSN

—

Volume of the periodical

24

Issue of the periodical within the volume

17

Country of publishing house

CH - SWITZERLAND

Number of pages

20

Pages from-to

3074

UT code for WoS article

000488613700054

EID of the result in the Scopus database

2-s2.0-85071514401