Mitochondrial targets of metformin-Are they physiologically relevant?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00509006" target="_blank" >RIV/61388963:_____/19:00509006 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/19:00510611
Result on the web
<a href="https://iubmb.onlinelibrary.wiley.com/doi/abs/10.1002/biof.1548" target="_blank" >https://iubmb.onlinelibrary.wiley.com/doi/abs/10.1002/biof.1548</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/biof.1548" target="_blank" >10.1002/biof.1548</a>
Alternative languages
Result language
angličtina
Original language name
Mitochondrial targets of metformin-Are they physiologically relevant?
Original language description
Metformin is the most widely prescribed treatment of hyperglycemia and type II diabetes since 1970s. During the last 15 years, its popularity increased due to epidemiological evidence, that metformin administration reduces incidence of cancer. However, despite the ongoing effort of many researchers, the molecular mechanisms underlying antihyperglycemic or antineoplastic action of metformin remain elusive. Most frequently, metformin is associated with modulation of mitochondrial metabolism leading to lowering of blood glucose or activation of antitumorigenic pathways. Here we review the reported effects of metformin on mitochondrial metabolism and their potential relevance as effective molecular targets with beneficial therapeutic outcome.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biofactors
ISSN
0951-6433
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
5
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
703-711
UT code for WoS article
000479406200001
EID of the result in the Scopus database
2-s2.0-85069902283