Structural basis for hijacking of the host ACBD3 protein by bovine and porcine enteroviruses and kobuviruses

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F20%3A00519394" target="_blank" >RIV/61388963:_____/20:00519394 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00705-019-04490-9" target="_blank" >https://link.springer.com/article/10.1007%2Fs00705-019-04490-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00705-019-04490-9" target="_blank" >10.1007/s00705-019-04490-9</a>

Result language
angličtina
Original language name
Structural basis for hijacking of the host ACBD3 protein by bovine and porcine enteroviruses and kobuviruses
Original language description
Picornaviruses infect a wide range of mammals including livestock such as cattle and swine. As with other picornavirus genera such as Aphthovirus, there is emerging evidence of a significant economic impact of livestock infections caused by members of the genera Enterovirus and Kobuvirus. While the human-infecting enteroviruses and kobuviruses have been intensively studied during the past decades in great detail, research on livestock-infecting viruses has been mostly limited to the genomic characterization of the viral strains identified worldwide. Here, we extend our previous studies of the structure and function of the complexes composed of the non-structural 3A proteins of human-infecting enteroviruses and kobuviruses and the host ACBD3 protein and present a structural and functional characterization of the complexes of the following livestock-infecting picornaviruses: bovine enteroviruses EV-E and EV-F, porcine enterovirus EV-G, and porcine kobuvirus AiV-C. We present a series of crystal structures of these complexes and demonstrate the role of these complexes in facilitation of viral replication.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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