Selective inhibition of neuronal Cav3.3 T-type calcium channels by TAT-based channel peptide

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F20%3A00525597" target="_blank" >RIV/61388963:_____/20:00525597 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/20:10413337

Result on the web

<a href="https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-020-00636-y" target="_blank" >https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-020-00636-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13041-020-00636-y" target="_blank" >10.1186/s13041-020-00636-y</a>

Result language

angličtina

Original language name

Selective inhibition of neuronal Cav3.3 T-type calcium channels by TAT-based channel peptide

Original language description

Low-voltage-activated Cav3 calcium channels (T-type) play an essential role in the functioning of the nervous system where they support oscillatory activities that relie on several channel molecular determinants that shape their unique gating properties. In a previous study, we documented the important role of the carboxy proximal region in the functioning of Cav3.3 channels. Here, we explore the ability of a TAT-based cell penetrating peptide containing this carboxy proximal region (TAT-C3P) to modulate the activity of Cav3 channels. We show that chronic application of TAT-C3P on tsA-201 cells expressing Cav3 channels selectively inhibits Cav3.3 channels without affecting Cav3.1 and Cav3.2 channels. Therefore, the TAT-C3P peptide described in this study represents a new tool to address the specific physiological role of Cav3.3 channels, and to potentially enhance our understanding of Cav3.3 in disease.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Brain

ISSN

1756-6606

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

Jun 19

Country of publishing house

GB - UNITED KINGDOM

Number of pages

3

Pages from-to

95

UT code for WoS article

000556296200001

EID of the result in the Scopus database

2-s2.0-85086752695