Triazoles and aromatase: The impact of copper cocktails

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F20%3A00531505" target="_blank" >RIV/61388963:_____/20:00531505 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/20:10413201 RIV/60460709:41210/20:81862 RIV/00216208:11510/20:10413201

Result on the web

<a href="https://doi.org/10.1016/j.envpol.2020.115201" target="_blank" >https://doi.org/10.1016/j.envpol.2020.115201</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.envpol.2020.115201" target="_blank" >10.1016/j.envpol.2020.115201</a>

Result language

angličtina

Original language name

Triazoles and aromatase: The impact of copper cocktails

Original language description

Triazoles are used as antifungal agents, they mostly inhibit two enzymes: 14α-demethylase and aromatase. These enzymes are utilised also in other species and therefore the affection in non-target species in the environment is expected as well. Besides, triazoles are often being applied in a mixture and they can also interact with other substances present. This study clarifies how three selected representative triazoles (tebuconazole, penconazole and cyproconazole) interact with each other (group effect) and in mixtures (cocktail effect) with copper, essential/toxic for all organisms. Within the experiments on electrospray and collision-induced dissociations (both ESI-MS), it has been found that the fragments correspond to typical triazole metabolites. For their formation, the presence of copper ions is crucial. The inhibitory effect of Cu cocktails on aromatase enzymatic activity has been studied. The presence of Cu ions together with triazole(s) significantly increases the inhibitory effect on aromatase activity. The highest inhibitory effect (more than 60%) on aromatase activity is produced by cocktails containing penconazole and Cu ions, namely by penconazole/Cu and penconazole/tebuconazole/Cu. The reactivity of triazoles in groups is not significantly affected by the interactions among them. Additionally, the role of triazoles in copper Fenton reaction regulation has been observed and described. These changes may be attributed to the formation and stabilization of the complexes with the central Cu ion, with usually one, two or three triazolic ligands, depending on the mixture. The study demonstrates that the interaction of triazoles and Cu ions is a complex process, their impact on metabolism seems to be rather extensive and must be evaluated in the context of biochemical reactions.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10406 - Analytical chemistry

Project

<a href="/en/project/GA18-01710S" target="_blank" >GA18-01710S: GROUP INTERACTIONS OF AZOLE PESTICIDES AND THEIR EFFECTS ON ESSENTIAL ENZYMES</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Pollution

ISSN

0269-7491

e-ISSN

—

Volume of the periodical

266

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

115201

UT code for WoS article

000572960600013

EID of the result in the Scopus database

2-s2.0-85088507720