Non-target biotransformation enzymes as a target for triazole-zinc mixtures
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00574688" target="_blank" >RIV/61388971:_____/23:00574688 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41210/23:94804 RIV/00216208:11310/23:10465865 RIV/00216208:11510/23:10465865
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0009279723002922?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0009279723002922?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cbi.2023.110625" target="_blank" >10.1016/j.cbi.2023.110625</a>
Alternative languages
Result language
angličtina
Original language name
Non-target biotransformation enzymes as a target for triazole-zinc mixtures
Original language description
Triazoles inhibit lanosterol 14 & alpha,-demethylase and block ergosterol biosynthesis in fungal pathogens. However, they also interact with other cytochrome P450 enzymes and influence non-target metabolic pathways. Disturbingly, triazoles may interact with essential elements. The interaction of penconazole (Pen), cyproconazole (Cyp) and tebuconazole (Teb) with Zn2+ results in the formation of deprotonated ligands in their complexes or in the creation of complexes with Cl- as a counterion or doubly charged complexes. Triazoles, as well as their equimolar cocktails with Zn2+ (10-6 mol/L), decreased the activities of the non-target enzymes CYP19A1 and CYP3A4. Pen most decreased CYP19A1 activity and was best bound to its active centre to block the catalytic cycle in computational analysis. For CYP3A4, Teb was found to be the most effective inhibitor by both, activity assay and interaction with the active centre. Teb/Cyp/Zn2+ and Teb/Pen/Cyp/Zn2+ cocktails also decreased the CYP19A1 activity, which was in correlation with the formation of numerous triazole-Zn2+ complexes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemico-Biological Interactions
ISSN
0009-2797
e-ISSN
1872-7786
Volume of the periodical
382
Issue of the periodical within the volume
1 September
Country of publishing house
IE - IRELAND
Number of pages
8
Pages from-to
110625
UT code for WoS article
001039350600001
EID of the result in the Scopus database
2-s2.0-85164817854