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Non-target biotransformation enzymes as a target for triazole-zinc mixtures

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00574688" target="_blank" >RIV/61388971:_____/23:00574688 - isvavai.cz</a>

  • Alternative codes found

    RIV/60460709:41210/23:94804 RIV/00216208:11310/23:10465865 RIV/00216208:11510/23:10465865

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S0009279723002922?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0009279723002922?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.cbi.2023.110625" target="_blank" >10.1016/j.cbi.2023.110625</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Non-target biotransformation enzymes as a target for triazole-zinc mixtures

  • Original language description

    Triazoles inhibit lanosterol 14 & alpha,-demethylase and block ergosterol biosynthesis in fungal pathogens. However, they also interact with other cytochrome P450 enzymes and influence non-target metabolic pathways. Disturbingly, triazoles may interact with essential elements. The interaction of penconazole (Pen), cyproconazole (Cyp) and tebuconazole (Teb) with Zn2+ results in the formation of deprotonated ligands in their complexes or in the creation of complexes with Cl- as a counterion or doubly charged complexes. Triazoles, as well as their equimolar cocktails with Zn2+ (10-6 mol/L), decreased the activities of the non-target enzymes CYP19A1 and CYP3A4. Pen most decreased CYP19A1 activity and was best bound to its active centre to block the catalytic cycle in computational analysis. For CYP3A4, Teb was found to be the most effective inhibitor by both, activity assay and interaction with the active centre. Teb/Cyp/Zn2+ and Teb/Pen/Cyp/Zn2+ cocktails also decreased the CYP19A1 activity, which was in correlation with the formation of numerous triazole-Zn2+ complexes.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Chemico-Biological Interactions

  • ISSN

    0009-2797

  • e-ISSN

    1872-7786

  • Volume of the periodical

    382

  • Issue of the periodical within the volume

    1 September

  • Country of publishing house

    IE - IRELAND

  • Number of pages

    8

  • Pages from-to

    110625

  • UT code for WoS article

    001039350600001

  • EID of the result in the Scopus database

    2-s2.0-85164817854