Transition‐Metal‐Mediated versus Tetrazine‐Triggered Bioorthogonal Release Reactions: Direct Comparison and Combinations Thereof
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F20%3A00532018" target="_blank" >RIV/61388963:_____/20:00532018 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/cplu.202000477" target="_blank" >https://doi.org/10.1002/cplu.202000477</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cplu.202000477" target="_blank" >10.1002/cplu.202000477</a>
Alternative languages
Result language
angličtina
Original language name
Transition‐Metal‐Mediated versus Tetrazine‐Triggered Bioorthogonal Release Reactions: Direct Comparison and Combinations Thereof
Original language description
Bioorthogonal cleavage reactions are gaining popularity in chemically inducible prodrug activation and in the control of biomolecular functions. Despite similar applications, these reactions were developed and optimized on different substrates and under different experimental conditions. Reported herein is a side-by-side comparison of palladium-, ruthenium- and tetrazine-triggered release reactions, which aims at comparing the reaction kinetics, efficiency and overall advantages and limitations of the methods. In addition, we disclose the possibility of mutual combination of the cleavage reactions. Finally, we compare the efficiency of the bioorthogonal deprotections in cellular experiments, which revealed that among the three methods investigated, the palladium- and the tetrazine-promoted reaction can be used for efficient prodrug activation, but only the tetrazine-triggered reactions proceed efficiently inside cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/GF20-30494L" target="_blank" >GF20-30494L: Bioorthogonal time-controlled intramitochondrial elimination</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemPlusChem
ISSN
2192-6506
e-ISSN
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Volume of the periodical
85
Issue of the periodical within the volume
8
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
1669-1675
UT code for WoS article
000563997000008
EID of the result in the Scopus database
2-s2.0-85089170465