Palladium-loaded PLGA-chitosan NPs as efficient catalysts for bioorthogonal chemistry
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43919616" target="_blank" >RIV/62156489:43210/20:43919616 - isvavai.cz</a>
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Palladium-loaded PLGA-chitosan NPs as efficient catalysts for bioorthogonal chemistry
Original language description
Bioorthogonal chemistry offers a wide range of reactions, which can be performed in the intracellular platform. Among the wide range of uses, bioorthogonal reactions can be employed for the controlled pro-drug activation in situ. Palladium compounds can be exploited as activation agents in the bioorthogonal reactions. However, their properties such as toxicity, poor cellular uptake and inactivation by biogenic thiols hinder their catalytic activity on the cellular level. In our study, we have prepared polymeric palladium-loaded poly(D,L-lactide-co-glycolide) (PLGA)-chitosan nanoparticles (NPs). The coating of these two polymers with chitosan has ensured cellular uptake and the gradual release of palladium compounds inside the cell. Their catalytic activity was demonstrated by the conversion of a fluorescent probe made of chemically modified 8-hydroxypyrene- 1,3,6-trisulfonic acid trisodium salt propargyl ether (HPTS-PE).
Czech name
—
Czech description
—
Classification
Type
D - Article in proceedings
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
MendelNet 2020: Proceedings of International PhD Students Conference
ISBN
978-80-7509-765-1
ISSN
—
e-ISSN
—
Number of pages
6
Pages from-to
572-577
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 11, 2020
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
—