Pyrido-Fused Deazapurine Bases: Synthesis and Glycosylation of 4-Substituted 9H-Pyrido[2′,3′:4,5]- and Pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F20%3A00534197" target="_blank" >RIV/61388963:_____/20:00534197 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/20:73606483 RIV/00216208:11310/20:10419497
Result on the web
<a href="https://doi.org/10.1021/acsomega.0c04302" target="_blank" >https://doi.org/10.1021/acsomega.0c04302</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsomega.0c04302" target="_blank" >10.1021/acsomega.0c04302</a>
Alternative languages
Result language
angličtina
Original language name
Pyrido-Fused Deazapurine Bases: Synthesis and Glycosylation of 4-Substituted 9H-Pyrido[2′,3′:4,5]- and Pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidines
Original language description
Two isomeric sets of 4-substituted pyridopyrrolopyrimidine nucleobases were prepared through nucleophilic substitutions or cross-coupling reactions of 4-chloropyridopyrrolopyrimidines. The corresponding 4-amino-pyridopyrrolopyrimidines were glycosylated with 5-O-tritylribose using the modified Mitsunobu protocol. Several examples of the title heterocycles showed blue or green fluorescence. Testing of the pyridopyrrolopyrimidine nucleobases for the cytotoxic effect revealed micromolar activity of 4-benzofuryl derivatives in both series, preferentially in multidrug-resistant cancers.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Omega
ISSN
2470-1343
e-ISSN
—
Volume of the periodical
5
Issue of the periodical within the volume
40
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
26278-26286
UT code for WoS article
000580943000083
EID of the result in the Scopus database
2-s2.0-85094187095