Phosphate linkers with traceable cyclic intermediates for self-immolation detection and monitoring

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F21%3A00539202" target="_blank" >RIV/61388963:_____/21:00539202 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/21:10438765
Result on the web
<a href="https://doi.org/10.1039/D0CC06928K" target="_blank" >https://doi.org/10.1039/D0CC06928K</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d0cc06928k" target="_blank" >10.1039/d0cc06928k</a>

Result language
angličtina
Original language name
Phosphate linkers with traceable cyclic intermediates for self-immolation detection and monitoring
Original language description
Self-immolation (SI) is the key principle of ProTide nucleotide prodrugs such as remdesivir, which is currently used to treat COVID-19 patients. Developing novel tailor-made SI systems requires new analytical methods for the detection and monitoring of SI. We developed a robust method for SI analysis using novel phosphate-based SI linkers with NMR traceable cyclic intermediates to distinguish SI from alternative fragmentation pathways and to monitor cargo release in real time.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10406 - Analytical chemistry

Project
<a href="/en/project/GJ20-25137Y" target="_blank" >GJ20-25137Y: Phoshate-based drug delivery spacers to target fungal infections</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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