Opioid Receptor Regulation of Neuronal Voltage-Gated Calcium Channels
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F21%3A00540957" target="_blank" >RIV/61388963:_____/21:00540957 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10429601
Result on the web
<a href="https://doi.org/10.1007/s10571-020-00894-3" target="_blank" >https://doi.org/10.1007/s10571-020-00894-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10571-020-00894-3" target="_blank" >10.1007/s10571-020-00894-3</a>
Alternative languages
Result language
angličtina
Original language name
Opioid Receptor Regulation of Neuronal Voltage-Gated Calcium Channels
Original language description
Neuronal voltage-gated calcium channels play a pivotal role in the conversion of electrical signals into calcium entry into nerve endings that is required for the release of neurotransmitters. They are under the control of a number of cellular signaling pathways that serve to fine tune synaptic activities, including G-protein coupled receptors (GPCRs) and the opioid system. Besides modulating channel activity via activation of second messengers, GPCRs also physically associate with calcium channels to regulate their function and expression at the plasma membrane. In this mini review, we discuss the mechanisms by which calcium channels are regulated by classical opioid and nociceptin receptors. We highlight the importance of this regulation in the control of neuronal functions and their implication in the development of disease conditions. Finally, we present recent literature concerning the use of novel μ-opioid receptor/nociceptin receptor modulators and discuss their use as potential drug candidates for the treatment of pain.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cellular and Molecular Neurobiology
ISSN
0272-4340
e-ISSN
1573-6830
Volume of the periodical
41
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
839-847
UT code for WoS article
000539386700001
EID of the result in the Scopus database
2-s2.0-85086018753