G Protein Regulation of Neuronal Calcium Channels: Back to the Future
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00444642" target="_blank" >RIV/61388963:_____/15:00444642 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1124/mol.114.096008" target="_blank" >http://dx.doi.org/10.1124/mol.114.096008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1124/mol.114.096008" target="_blank" >10.1124/mol.114.096008</a>
Alternative languages
Result language
angličtina
Original language name
G Protein Regulation of Neuronal Calcium Channels: Back to the Future
Original language description
Neuronal voltage-gated calcium channels have evolved as one of the most important players for calcium entry into presynaptic endings responsible for the release of neurotransmitters. In turn, and to fine-tune synaptic activity and neuronal communication,numerous neurotransmitters exert a potent negative feedback over the calcium signal provided by G protein-coupled receptors. This regulation pathway of physiologic importance is also extensively exploited for therapeutic purposes, for instance in the treatment of neuropathic pain by morphine and other mu-opioid receptor agonists. However, despite more than three decades of intensive research, important questions remain unsolved regarding the molecular and cellular mechanisms of direct G protein inhibition of voltage-gated calcium channels. In this study, we revisit this particular regulation and explore new considerations.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA15-13556S" target="_blank" >GA15-13556S: Pathophysiology of T-type calcium channels in diabetic neuropathy</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Pharmacology
ISSN
0026-895X
e-ISSN
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Volume of the periodical
87
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
890-906
UT code for WoS article
000354617000001
EID of the result in the Scopus database
2-s2.0-84936136177