Phosphate-Based Self-Immolative Linkers for the Delivery of Amine-Containing Drugs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F21%3A00545329" target="_blank" >RIV/61388963:_____/21:00545329 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/21:10431109
Result on the web
<a href="https://doi.org/10.3390/molecules26175160" target="_blank" >https://doi.org/10.3390/molecules26175160</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules26175160" target="_blank" >10.3390/molecules26175160</a>

Result language
angličtina
Original language name
Phosphate-Based Self-Immolative Linkers for the Delivery of Amine-Containing Drugs
Original language description
Amine-containing drugs often show poor pharmacological properties, but these disadvantages can be overcome by using a prodrug approach involving self-immolative linkers. Accordingly, we designed l-lactate linkers as ideal candidates for amine delivery. Furthermore, we designed linkers bearing two different cargos (aniline and phenol) for preferential amine cargo release within 15 min. Since the linkers carrying secondary amine cargo showed high stability at physiological pH, we used our strategy to prepare phosphate-based prodrugs of the antibiotic Ciprofloxacin. Therefore, our study will facilitate the rational design of new and more effective drug delivery systems for amine-containing drugs.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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