Phosphate-Based Self-Immolative Linkers for Tuneable Double Cargo Release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F21%3A00544662" target="_blank" >RIV/61388963:_____/21:00544662 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/21:10431105
Result on the web
<a href="https://doi.org/10.1002/chem.202101805" target="_blank" >https://doi.org/10.1002/chem.202101805</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/chem.202101805" target="_blank" >10.1002/chem.202101805</a>
Alternative languages
Result language
angličtina
Original language name
Phosphate-Based Self-Immolative Linkers for Tuneable Double Cargo Release
Original language description
Phosphorus-based self-immolative (SI) linkers offer a wide range of applications, such as smart materials and drug-delivery systems. Phosphorus SI linkers are ideal candidates for double-cargo delivery platforms because they have a higher valency than carbon. A series of substituted phosphate linkers was designed for releasing two phenolic cargos through SI followed by chemical hydrolysis. Suitable modifications of the lactate spacer increased the cargo release rate significantly, from 1 day to 2 hours or 5 minutes, as shown for linkers containing p-fluoro phenol. In turn, double cargo linkers bearing p-methyl phenol released their cargo more slowly (4 days, 4 hours, and 15 minutes) than their p-fluoro analogues. The α-hydroxyisobutyrate linker released both cargos in 25 minutes. Our study expands the current portfolio of SI constructs by providing a double cargo delivery option, which is crucial to develop universal SI platforms.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemistry - A European Journal
ISSN
0947-6539
e-ISSN
1521-3765
Volume of the periodical
27
Issue of the periodical within the volume
50
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
12763-12775
UT code for WoS article
000678660700001
EID of the result in the Scopus database
2-s2.0-85111473594