Lipid Nanoparticles for Broad-Spectrum Nucleic Acid Delivery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F21%3A00545469" target="_blank" >RIV/61388963:_____/21:00545469 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/21:00545469 RIV/00216208:11110/21:10430494 RIV/00216208:11310/21:10430494
Result on the web
<a href="https://doi.org/10.1002/adfm.202101391" target="_blank" >https://doi.org/10.1002/adfm.202101391</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adfm.202101391" target="_blank" >10.1002/adfm.202101391</a>
Alternative languages
Result language
angličtina
Original language name
Lipid Nanoparticles for Broad-Spectrum Nucleic Acid Delivery
Original language description
Lipid nanoparticles (LNPs) are the most advanced nonviral modality for nucleic acid (NA) delivery, and have recently gained enormous attention in the fields of RNA therapeutics and vaccine development. Here, ionizable adamantane-based lipidoids named XMaNs, which circumvent the usual need for laborious optimization of LNP components for highly diverse types of NAs, are described. The non-toxic XMaN6 lipidoid is highly versatile in entrapment and delivery of siRNA, mRNA, plasmid DNA, and a cyclic dinucleotide. XMaN6-based LNPs efficiently deliver: 1) siRNA into human primary hepatocytes and cell lines that are hard-to-transfect, 2) mRNA into mouse liver, 3) plasmid DNA, 4) 2′,3′-cGAMP into cells and activated the cGAS-STING pathway three orders of magnitude more efficiently than 2′,3′-cGAMP alone. To our knowledge, such universality in delivering different NA types has not been previously described and can accelerate translation of LNPs into the clinic.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Functional Materials
ISSN
1616-301X
e-ISSN
1616-3028
Volume of the periodical
31
Issue of the periodical within the volume
47
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
2101391
UT code for WoS article
000688518800001
EID of the result in the Scopus database
2-s2.0-85113371724