Self-Assembly, Drug Encapsulation, and Cellular Uptake of Block and Gradient Copolymers of 2-Methyl-2-oxazine and 2- n-Propyl/butyl-2-oxazoline
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F21%3A00549833" target="_blank" >RIV/61388963:_____/21:00549833 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/21:00549608 RIV/00216208:11110/21:10437543 RIV/00216208:11320/21:10437543 RIV/00216208:11310/21:10437543
Result on the web
<a href="https://doi.org/10.1021/acs.macromol.1c01794" target="_blank" >https://doi.org/10.1021/acs.macromol.1c01794</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.macromol.1c01794" target="_blank" >10.1021/acs.macromol.1c01794</a>
Alternative languages
Result language
angličtina
Original language name
Self-Assembly, Drug Encapsulation, and Cellular Uptake of Block and Gradient Copolymers of 2-Methyl-2-oxazine and 2- n-Propyl/butyl-2-oxazoline
Original language description
Self-assembled amphiphilic polymers have been extensively studied for various biomedical applications, as they show advantageous properties for diagnosis and therapy. In this work, we extensively compared amphiphilic copolymers of the hydrophilic monomer 2-methyl-2-oxazine (MeOzi) and the thermoresponsive or hydrophobic monomers 2-propyl-2-oxazoline (PrOx) or 2-butyl-2-oxazoline (BuOx) in both block and gradient monomer distributions. Such a head-to-head comparison between block and gradient copolymers, which has thus far been mostly missing in the available literature, should provide important insight into the differences and similarities between these two architectures. We investigated the properties of our polymers using a wide array of analytical methods, including dynamic light scattering (DLS), small-angle neutron (SANS) and X-ray scattering (SAXS), one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy, transmission electron microscopy (TEM), drug loading (DL), cellular uptake, and cytotoxicity studies. Most of the studied polymers formed self-assembled nanoparticles, but their properties varied with the monomer ratio, polymer length, and polymer architecture, and these factors could be used to fine-tune the properties of the polymer to meet the demands of the desired application. Both block and gradient copolymers showed similar critical association concentrations and DL properties for the antituberculosis drug rifampicin. Finally, we confirmed that the nanoparticles could be internalized by macrophages, which indicates great potential for the utilization of these nanoparticles in drug delivery.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/GA19-01602S" target="_blank" >GA19-01602S: Self-assembled structures of amphiphilic gradient copolymers for conceptually new applications</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecules
ISSN
0024-9297
e-ISSN
1520-5835
Volume of the periodical
54
Issue of the periodical within the volume
23
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
10667-10681
UT code for WoS article
000752886100004
EID of the result in the Scopus database
2-s2.0-85120725708