Peptides before and during the nucleotide world: An origins story emphasizing cooperation between proteins and nucleic acids

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00556704" target="_blank" >RIV/61388963:_____/22:00556704 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/22:10450669

Result on the web

<a href="https://doi.org/10.1098/rsif.2021.0641" target="_blank" >https://doi.org/10.1098/rsif.2021.0641</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1098/rsif.2021.0641" target="_blank" >10.1098/rsif.2021.0641</a>

Result language

angličtina

Original language name

Peptides before and during the nucleotide world: An origins story emphasizing cooperation between proteins and nucleic acids

Original language description

Recent developments in Origins of Life research have focused on substantiating the narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular weight, a paradigm that typically sidelines the roles of peptides. Nevertheless, the simple synthesis of amino acids, the facile nature of their activation and condensation, their ability to recognize metals and cofactors and their remarkable capacity to self-assemble make peptides (and their analogues) favourable candidates for one of the earliest functional polymers. In this mini-review, we explore the ramifications of this hypothesis. Diverse lines of research in molecular biology, bioinformatics, geochemistry, biophysics and astrobiology provide clues about the progression and early evolution of proteins, and lend credence to the idea that early peptides served many central prebiotic roles before they were encodable by a polynucleotide template, in a putative 'peptide-polynucleotide stage'. For example, early peptides and mini-proteins could have served as catalysts, compartments and structural hubs. In sum, we shed light on the role of early peptides and small proteins before and during the nucleotide world, in which nascent life fully grasped the potential of primordial proteins, and which has left an imprint on the idiosyncratic properties of extant proteins.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/EF19_073%2F0016935" target="_blank" >EF19_073/0016935: Grant schemes at Charles University</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the Royal Society Interface

ISSN

1742-5689

e-ISSN

1742-5662

Volume of the periodical

19

Issue of the periodical within the volume

187

Country of publishing house

GB - UNITED KINGDOM

Number of pages

18

Pages from-to

20210641

UT code for WoS article

000791277600002

EID of the result in the Scopus database

2-s2.0-85124253830