Coenzyme-protein interactions since early life

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F25%3A00643382" target="_blank" >RIV/61388963:_____/25:00643382 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/25:10508690

Result on the web

<a href="https://doi.org/10.7554/eLife.94174" target="_blank" >https://doi.org/10.7554/eLife.94174</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/eLife.94174" target="_blank" >10.7554/eLife.94174</a>

Result language

angličtina

Original language name

Coenzyme-protein interactions since early life

Original language description

Recent findings in protein evolution and peptide prebiotic plausibility have been setting the stage for reconsidering the role of peptides in the early stages of life's origin. Ancient protein families have been found to share common themes and proteins reduced in composition to prebiotically plausible amino acids have been reported capable of structure formation and key functions, such as binding to RNA. While this may suggest peptide relevance in early life, their functional repertoire, when composed of a limited number of early residues (missing some of the most sophisticated functional groups of today's alphabet) has been debated. Cofactors enrich the functional scope of about half of extant enzymes, but whether they could also bind to peptides lacking the evolutionary late amino acids remains speculative. The aim of this study was to resolve the early peptide propensity to bind organic cofactors by analysis of protein-coenzyme interactions across the Protein Data Bank (PDB). We find that the prebiotically plausible amino acids are more abundant in the binding sites of the most ancient coenzymes and that such interactions rely more frequently on the involvement of the protein backbone atoms and metal ion cofactors. Moreover, we have identified a few select examples in today's enzymes where coenzyme binding is supported solely by prebiotically available amino acids. These results imply the plausibility of a coenzyme-peptide functional collaboration preceding the establishment of the Central Dogma and full protein alphabet evolution.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

eLife

ISSN

2050-084X

e-ISSN

2050-084X

Volume of the periodical

13

Issue of the periodical within the volume

December

Country of publishing house

GB - UNITED KINGDOM

Number of pages

20

Pages from-to

RP94174

UT code for WoS article

001631169700001

EID of the result in the Scopus database

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