Synthesis of sulfur karrikin bioisosteres as potential neuroprotectives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00558020" target="_blank" >RIV/61388963:_____/22:00558020 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.3762/bjoc.18.57" target="_blank" >https://doi.org/10.3762/bjoc.18.57</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3762/bjoc.18.57" target="_blank" >10.3762/bjoc.18.57</a>

Result language
angličtina
Original language name
Synthesis of sulfur karrikin bioisosteres as potential neuroprotectives
Original language description
The only known sulfur-containing karrikin, 3-methyl-2H-thiopyrano[3,4-b]furan-2-one, has been recently identified as an extremely efficient neuroprotective butenolide. Herein, we report the targeted synthesis of this compound as well as new synthetic protocols toward a class of compounds derived from 2H-furo[2,3-c]pyran-2-ones (karrikins) via bioisosteric exchange of oxygen with sulfur. In particular, we present synthetic procedures toward bioisosteres of karrikins with one or two sulfur heteroatoms incorporated into the core backbone together with evaluation of their biological activity in inhibition of acetylcholinesterase.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/GA20-11571S" target="_blank" >GA20-11571S: Butenolides with neuroprotective effect from plant-derived smoke and their synthetic derivatives</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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