Nanodiamond-Quantum Sensors Reveal Temperature Variation Associated to Hippocampal Neurons Firing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00559552" target="_blank" >RIV/61388963:_____/22:00559552 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10445724
Result on the web
<a href="https://doi.org/10.1002/advs.202202014" target="_blank" >https://doi.org/10.1002/advs.202202014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/advs.202202014" target="_blank" >10.1002/advs.202202014</a>
Alternative languages
Result language
angličtina
Original language name
Nanodiamond-Quantum Sensors Reveal Temperature Variation Associated to Hippocampal Neurons Firing
Original language description
Temperature is one of the most relevant parameters for the regulation of intracellular processes. Measuring localized subcellular temperature gradients is fundamental for a deeper understanding of cell function, such as the genesis of action potentials, and cell metabolism. Notwithstanding several proposed techniques, at the moment detection of temperature fluctuations at the subcellular level still represents an ongoing challenge. Here, for the first time, temperature variations (1 °C) associated with potentiation and inhibition of neuronal firing is detected, by exploiting a nanoscale thermometer based on optically detected magnetic resonance in nanodiamonds. The results demonstrate that nitrogen-vacancy centers in nanodiamonds provide a tool for assessing various levels of neuronal spiking activity, since they are suitable for monitoring different temperature variations, respectively, associated with the spontaneous firing of hippocampal neurons, the disinhibition of GABAergic transmission and the silencing of the network. Conjugated with the high sensitivity of this technique (in perspective sensitive to < 0.1 °C variations), nanodiamonds pave the way to a systematic study of the generation of localized temperature gradients under physiological and pathological conditions. Furthermore, they prompt further studies explaining in detail the physiological mechanism originating this effect.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
<a href="/en/project/EF16_026%2F0008382" target="_blank" >EF16_026/0008382: Carbon allotropes with rationalized nanointerfaces and nanolinks for environmental and biomedical applications</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Science
ISSN
2198-3844
e-ISSN
2198-3844
Volume of the periodical
9
Issue of the periodical within the volume
28
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
2202014
UT code for WoS article
000830459300001
EID of the result in the Scopus database
2-s2.0-85134571799