Pushing the Limits of Nucleic Acid Function

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00563450" target="_blank" >RIV/61388963:_____/22:00563450 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1002/chem.202201737" target="_blank" >https://doi.org/10.1002/chem.202201737</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/chem.202201737" target="_blank" >10.1002/chem.202201737</a>

Result language

angličtina

Original language name

Pushing the Limits of Nucleic Acid Function

Original language description

For many decades it was thought that information storage and information transfer were the main functions of nucleic acids. However, artificial evolution experiments have shown that the functional potential of DNA and RNA is much greater. Here I provide an overview of this technique and highlight recent advances which have increased its potency. I also describe how artificial evolution has been used to identify nucleic acids with extreme functions. These include deoxyribozymes that generate unusual products such as light, tiny motifs made up of fewer than ten nucleotides, ribozymes that catalyze complex reactions such as RNA polymerization, information-rich sequences that encode overlapping ribozymes, motifs that catalyze reactions at rates too fast to be followed by manual pipetting, and functional nucleic acids which are active in extreme conditions. Such motifs highlight the limits of our knowledge and provide clues about as of yet undiscovered functions of DNA and RNA.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/EF16_019%2F0000729" target="_blank" >EF16_019/0000729: Chemical biology for drugging undruggable targets</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemistry - A European Journal

ISSN

0947-6539

e-ISSN

1521-3765

Volume of the periodical

28

Issue of the periodical within the volume

71

Country of publishing house

DE - GERMANY

Number of pages

13

Pages from-to

e202201737

UT code for WoS article

000871924600001

EID of the result in the Scopus database

2-s2.0-85140452151