Cyclen based compounds, coordination compounds, peptides, pharmaceutical preparation, and use thereof
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00573119" target="_blank" >RIV/61388963:_____/22:00573119 - isvavai.cz</a>
Result on the web
<a href="https://worldwide.espacenet.com/patent/search/family/067070628/publication/AU2020306219A1?q=AU%202020306219B2" target="_blank" >https://worldwide.espacenet.com/patent/search/family/067070628/publication/AU2020306219A1?q=AU%202020306219B2</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Cyclen based compounds, coordination compounds, peptides, pharmaceutical preparation, and use thereof
Original language description
The present invention relates to cyclen based compounds of general formula (I), wherein X is nitrogen and Y, Z are –CH-, or X, Z are –CH- and Y is nitrogen, or X, Y are –CH- and Z is nitrogen, R1 is independently selected from H, COOH, benzyloxycarbonyl, fluorenylmethyloxycarbonyl, tert-butoxycarbonyl, methylcarbonyl, trifluoromethylcarbonyl, benzyl, triphenylmethyl, tosyl, mesyl, benzyloxymethyl, phenylsulfonyl, ethoxycarbonyl, 2,2,2-trichloroethyloxycarbonyl, methoxycarbonyl, methoxymethyloxycarbonyl, R2 is selected from H, methylcarbonyl, tert-butyldimethylsilyl, (C1-C4)alkyl, which can be linear or branched, and which can optionally be substituted with CH3O-, CH3S-, oxacyclohexyl, allyl, tert-butyldiphenylsilyl, tert-butylcarbonyl, phenylcarbonyl, nitrobenzyl, benzyloxymethyl, which can optionally be substituted with CH3O-, -NO2, fluorenylmethyloxycarbonyl, trichlorocarbonyl, trifluorocarbonyl, benzyl, tosyl, mesyl, phenylsulfonyl, allylsulphonyl, ethoxycarbonyl, 2,2,2-trichloroethyloxycarbonyl, methoxycarbonyl, methoxymethyloxycarbonyl, R3 is independently selected from H, (C1-C6)alkyl, which can be linear or branched, and which can optionally be substituted with -CH3, -C1, -F, -CN, tosyl, triisopropylsilyl, CH3O-, CH3S-, (C5-C6)cycloalkyl, which can optionally be substituted with -CH3, -C1, -F, -CN, (C6-C10)aryl, which can optionally be substituted with -CH3, -C1, -F, -CN, allyl, propargyl, fluorenylmethyl, benzoylmethyl, phenyloxymethyl, oxacyclopentyl, 2-oxo-1,2-diphenylethyl, with the proviso that where R1 is bound to nitrogen, then R1 is not COOH, with the proviso that where R1 is bound to –CH-, then R1 is independently H or COOH, and with the proviso that one R1 is COOH, and with the proviso that one –CH-R1 group is –CH2-. The invention further relates to its coordination compounds, peptides and pharmaceutical preparations, as well as to the medical use thereof.
Czech name
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Czech description
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Classification
Type
P - Patent
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/GJ17-22834Y" target="_blank" >GJ17-22834Y: Synthesis and screening of selective probes for magnetic resonance imaging</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Patent/design ID
AU2020306219
Publisher
AU001 -
Publisher name
IP Australia
Place of publication
Phillip ACT
Publication country
AU - AUSTRALIA
Date of acceptance
Nov 17, 2022
Owner name
Ústav organické chemie a biochemie AV ČR, v. v. i
Method of use
A - Výsledek využívá pouze poskytovatel
Usage type
A - K využití výsledku jiným subjektem je vždy nutné nabytí licence