Cyclen based compounds, coordination compounds, peptides, pharmaceutical preparation, and use thereof

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00573186" target="_blank" >RIV/61388963:_____/23:00573186 - isvavai.cz</a>

Result on the web

<a href="https://worldwide.espacenet.com/patent/search/family/067070628/publication/EP3959208B1?q=EP3959208B1" target="_blank" >https://worldwide.espacenet.com/patent/search/family/067070628/publication/EP3959208B1?q=EP3959208B1</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Cyclen based compounds, coordination compounds, peptides, pharmaceutical preparation, and use thereof

Original language description

The present invention relates to cyclen based compounds of general formula (I), wherein X is nitrogen and Y, Z are –CH-, or X, Z are –CH- and Y is nitrogen, or X, Y are –CH- and Z is nitrogen, R1 is independently selected from H, COOH, benzyloxycarbonyl, fluorenylmethyloxycarbonyl, tert-butoxycarbonyl, methylcarbonyl, trifluoromethylcarbonyl, benzyl, triphenylmethyl, tosyl, mesyl, benzyloxymethyl, phenylsulfonyl, ethoxycarbonyl, 2,2,2-trichloroethyloxycarbonyl, methoxycarbonyl, methoxymethyloxycarbonyl, R2 is selected from H, methylcarbonyl, tert-butyldimethylsilyl, (C1-C4)alkyl, which can be linear or branched, and which can optionally be substituted with CH3O-, CH3S-, oxacyclohexyl, allyl, tert-butyldiphenylsilyl, tert-butylcarbonyl, phenylcarbonyl, nitrobenzyl, benzyloxymethyl, which can optionally be substituted with CH3O-, -NO2, fluorenylmethyloxycarbonyl, trichlorocarbonyl, trifluorocarbonyl, benzyl, tosyl, mesyl, phenylsulfonyl, allylsulphonyl, ethoxycarbonyl, 2,2,2-trichloroethyloxycarbonyl, methoxycarbonyl, methoxymethyloxycarbonyl, R3 is independently selected from H, (C1-C6)alkyl, which can be linear or branched, and which can optionally be substituted with -CH3, -C1, -F, -CN, tosyl, triisopropylsilyl, CH3O-, CH3S-, (C5-C6)cycloalkyl, which can optionally be substituted with -CH3, -C1, -F, -CN, (C6-C10)aryl, which can optionally be substituted with -CH3, -C1, -F, -CN, allyl, propargyl, fluorenylmethyl, benzoylmethyl, phenyloxymethyl, oxacyclopentyl, 2-oxo-1,2-diphenylethyl, with the proviso that where R1 is bound to nitrogen, then R1 is not COOH, with the proviso that where R1 is bound to –CH-, then R1 is independently H or COOH, and with the proviso that one R1 is COOH, and with the proviso that one –CH-R1 group is –CH2-. The invention further relates to its coordination compounds, peptides and pharmaceutical preparations, as well as to the medical use thereof.

Czech name

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Czech description

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Type

P - Patent

CEP classification

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OECD FORD branch

10401 - Organic chemistry

Project

<a href="/en/project/GJ17-22834Y" target="_blank" >GJ17-22834Y: Synthesis and screening of selective probes for magnetic resonance imaging</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Patent/design ID

EP3959208

Publisher

EPO_1 -

Publisher name

European Patent Office

Place of publication

Munich, The Hague, Berlin, Vienna, Brussels

Publication country

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Date of acceptance

Jul 5, 2023

Owner name

Ústav organické chemie a biochemie AV ČR, v. v. i

Method of use

A - Výsledek využívá pouze poskytovatel

Usage type

A - K využití výsledku jiným subjektem je vždy nutné nabytí licence