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Cyclen based compounds, coordination compounds, peptides, pharmaceutical preparation, and use thereof

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00573186" target="_blank" >RIV/61388963:_____/23:00573186 - isvavai.cz</a>

  • Result on the web

    <a href="https://worldwide.espacenet.com/patent/search/family/067070628/publication/EP3959208B1?q=EP3959208B1" target="_blank" >https://worldwide.espacenet.com/patent/search/family/067070628/publication/EP3959208B1?q=EP3959208B1</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cyclen based compounds, coordination compounds, peptides, pharmaceutical preparation, and use thereof

  • Original language description

    The present invention relates to cyclen based compounds of general formula (I), wherein X is nitrogen and Y, Z are –CH-, or X, Z are –CH- and Y is nitrogen, or X, Y are –CH- and Z is nitrogen, R1 is independently selected from H, COOH, benzyloxycarbonyl, fluorenylmethyloxycarbonyl, tert-butoxycarbonyl, methylcarbonyl, trifluoromethylcarbonyl, benzyl, triphenylmethyl, tosyl, mesyl, benzyloxymethyl, phenylsulfonyl, ethoxycarbonyl, 2,2,2-trichloroethyloxycarbonyl, methoxycarbonyl, methoxymethyloxycarbonyl, R2 is selected from H, methylcarbonyl, tert-butyldimethylsilyl, (C1-C4)alkyl, which can be linear or branched, and which can optionally be substituted with CH3O-, CH3S-, oxacyclohexyl, allyl, tert-butyldiphenylsilyl, tert-butylcarbonyl, phenylcarbonyl, nitrobenzyl, benzyloxymethyl, which can optionally be substituted with CH3O-, -NO2, fluorenylmethyloxycarbonyl, trichlorocarbonyl, trifluorocarbonyl, benzyl, tosyl, mesyl, phenylsulfonyl, allylsulphonyl, ethoxycarbonyl, 2,2,2-trichloroethyloxycarbonyl, methoxycarbonyl, methoxymethyloxycarbonyl, R3 is independently selected from H, (C1-C6)alkyl, which can be linear or branched, and which can optionally be substituted with -CH3, -C1, -F, -CN, tosyl, triisopropylsilyl, CH3O-, CH3S-, (C5-C6)cycloalkyl, which can optionally be substituted with -CH3, -C1, -F, -CN, (C6-C10)aryl, which can optionally be substituted with -CH3, -C1, -F, -CN, allyl, propargyl, fluorenylmethyl, benzoylmethyl, phenyloxymethyl, oxacyclopentyl, 2-oxo-1,2-diphenylethyl, with the proviso that where R1 is bound to nitrogen, then R1 is not COOH, with the proviso that where R1 is bound to –CH-, then R1 is independently H or COOH, and with the proviso that one R1 is COOH, and with the proviso that one –CH-R1 group is –CH2-. The invention further relates to its coordination compounds, peptides and pharmaceutical preparations, as well as to the medical use thereof.

  • Czech name

  • Czech description

Classification

  • Type

    P - Patent

  • CEP classification

  • OECD FORD branch

    10401 - Organic chemistry

Result continuities

  • Project

    <a href="/en/project/GJ17-22834Y" target="_blank" >GJ17-22834Y: Synthesis and screening of selective probes for magnetic resonance imaging</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Patent/design ID

    EP3959208

  • Publisher

    EPO_1 -

  • Publisher name

    European Patent Office

  • Place of publication

    Munich, The Hague, Berlin, Vienna, Brussels

  • Publication country

  • Date of acceptance

    Jul 5, 2023

  • Owner name

    Ústav organické chemie a biochemie AV ČR, v. v. i

  • Method of use

    A - Výsledek využívá pouze poskytovatel

  • Usage type

    A - K využití výsledku jiným subjektem je vždy nutné nabytí licence