Pathophysiology of ion channels in amyotrophic lateral sclerosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00579977" target="_blank" >RIV/61388963:_____/23:00579977 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/23:43926240
Result on the web
<a href="https://doi.org/10.1186/s13041-023-01070-6" target="_blank" >https://doi.org/10.1186/s13041-023-01070-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13041-023-01070-6" target="_blank" >10.1186/s13041-023-01070-6</a>
Alternative languages
Result language
angličtina
Original language name
Pathophysiology of ion channels in amyotrophic lateral sclerosis
Original language description
Amyotrophic lateral sclerosis (ALS) stands as the most prevalent and severe form of motor neuron disease, affecting an estimated 2 in 100,000 individuals worldwide. It is characterized by the progressive loss of cortical, brainstem, and spinal motor neurons, ultimately resulting in muscle weakness and death. Although the etiology of ALS remains poorly understood in most cases, the remodelling of ion channels and alteration in neuronal excitability represent a hallmark of the disease, manifesting not only during the symptomatic period but also in the early pre-symptomatic stages. In this review, we delve into these alterations observed in ALS patients and preclinical disease models, and explore their consequences on neuronal activities. Furthermore, we discuss the potential of ion channels as therapeutic targets in the context of ALS.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Brain
ISSN
1756-6606
e-ISSN
1756-6606
Volume of the periodical
16
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
17
Pages from-to
82
UT code for WoS article
001125183000001
EID of the result in the Scopus database
2-s2.0-85179897836