Pathophysiology of Amyotrophic Lateral Sclerosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00491725" target="_blank" >RIV/68378041:_____/17:00491725 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Pathophysiology of Amyotrophic Lateral Sclerosis
Original language description
Amiotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurones in the brain and the spinal cord, resulting in the progressive decline of functions, muscle atrophy and fatal outcome. Despite increasing knowledge in our understanding of the genetics and mechanisms of ALS, the discovery of candidate markers for diagnosis and new agents that experimentally modify the course of the disease, we are still unable to predict, prevent, postpone or treat this malady in patients. Here we present a comprehensive review of the latest discoveries in the genetics and pathophysiology of ALS and introduce the animal models of ALS which can help scientists to understand the mechanisms underlying motor neuronal death and the effects of various therapeutic approaches.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/LO1309" target="_blank" >LO1309: Cell Therapy and Tissue Repair</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Nanomaterials in Biomedical research
ISBN
978-80-906655-5-2
Number of pages of the result
6
Pages from-to
90-95
Number of pages of the book
140
Publisher name
Proxima Tisk, s.r.o.
Place of publication
Praha 3
UT code for WoS chapter
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