The Endocannabinoid System - The Prediction of Spontaneous Preterm Birth in High-Risk Women: Protocol of a Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00580703" target="_blank" >RIV/61388963:_____/23:00580703 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/23:00580703 RIV/00216224:14110/23:00133344 RIV/00216208:11110/23:10473519 RIV/00064165:_____/23:10473519

Result on the web

<a href="https://doi.org/10.33549/physiolres.935230" target="_blank" >https://doi.org/10.33549/physiolres.935230</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.935230" target="_blank" >10.33549/physiolres.935230</a>

Result language

angličtina

Original language name

The Endocannabinoid System - The Prediction of Spontaneous Preterm Birth in High-Risk Women: Protocol of a Study

Original language description

Spontaneous preterm birth (sPTB) is a major cause of perinatal morbidity and mortality, even in developed countries. Prediction of sPTB is therefore a valuable tool to reduce the associated risks. The current standard for the prediction of sPTB consists, in addition to anamnestic data, of previous sPTB and previous second trimester miscarriage, measurement of cervical length by transvaginal ultrasound (TVU CL) together with assessment of fetal fibronectin levels in cervicovaginal fluid. Other evaluation parameters, such as the level of endocannabinoids in the pregnant woman's blood, could increase the sensitivity of this management. Endocannabinoids (eCBs) are a part of the endocannabinoid system (ECS), out of them anandamide (arachidonoyl-ethanolamide, AEA), in particular, plays an important role in the regulation of pregnancy and childbirth. We present the protocol for an open, non-randomized study to evaluate concentrations of AEA and other endocannabinoids: 2-linoleoylglycerol (2-AG), 2-linoleoylglycerol (2-LG), 2-oleoylgly-cerol (2-OG), and 2-arachidonoyldopamine (2-ADOPA or also NADA) in the blood of pregnant women as potential predictors of sPTB. In a total of 230 women with a history of sPTB or miscarriage, eCBs levels between 22 and 28 weeks of gestation will be assessed from maternal blood, in addition to the standard procedure. The aim of the study is to determine the relationship between blood concentrations of the endocanna-binoids tested and the risk of sPTB. The results of this study will describe the prognostic significance of maternal blood eCBs levels for sPTB, and could subsequently enable improved screening programs for early identification of sPTB.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

1802-9973

Volume of the periodical

72

Issue of the periodical within the volume

Suppl. 4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

"S381"-"S387"

UT code for WoS article

001127421100002

EID of the result in the Scopus database

2-s2.0-85180419621