The linker histone H1-BRCA1 axis is a crucial mediator of replication fork stability
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00582794" target="_blank" >RIV/61388963:_____/23:00582794 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.26508/lsa.202301933" target="_blank" >https://doi.org/10.26508/lsa.202301933</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.26508/lsa.202301933" target="_blank" >10.26508/lsa.202301933</a>
Alternative languages
Result language
angličtina
Original language name
The linker histone H1-BRCA1 axis is a crucial mediator of replication fork stability
Original language description
The maintenance of genome integrity relies on replication fork stabilization upon encountering endogenous and exogenous sources of DNA damage. How this process is coordinated with the local chromatin environment remains poorly defined. Here, we show that the replication-dependent histone H1 variants interact with the tumour suppressor BRCA1 in a replication stress- dependent manner. Transient loss of the replication-dependent histones H1 does not affect fork progression in unchallenged conditions but leads to the accumulation of stalled replication intermediates. Upon challenge with hydroxyurea, cells deficient for histone H1 variants fail to recruit BRCA1 to stalled replication forks and undergo MRE11-dependent fork resection and collapse, which ultimately leads to genomic instability and cell death. In summary, our work defines an essential role of the replicationdependent histone H1 variants in mediating BRCA1-dependent fork protection and genome stability.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Life Science Alliance
ISSN
2575-1077
e-ISSN
2575-1077
Volume of the periodical
6
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
e202301933
UT code for WoS article
001022779800002
EID of the result in the Scopus database
2-s2.0-85163290315