Glyco-DNA: Enzymatic Synthesis of Base-modified and Hypermodified DNA Displaying up to Four Different Monosaccharide Units in the Major Groove
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00587089" target="_blank" >RIV/61388963:_____/24:00587089 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10495168
Result on the web
<a href="https://doi.org/10.1002/chem.202402318" target="_blank" >https://doi.org/10.1002/chem.202402318</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/chem.202402318" target="_blank" >10.1002/chem.202402318</a>
Alternative languages
Result language
angličtina
Original language name
Glyco-DNA: Enzymatic Synthesis of Base-modified and Hypermodified DNA Displaying up to Four Different Monosaccharide Units in the Major Groove
Original language description
A portfolio of six modified 2'-deoxyribonucleoside triphosphate (dNTP) derivatives derived from 5-substituted pyrimidine or 7- substituted 7-deazapurine bearing different carbohydrate units (D-glucose, D-galactose, D-mannose, L-fucose, sialic acid and N-Ac-Dgalactosamine) tethered through propargyl-glycoside linker was designed and synthesized via the Sonogashira reactions of halogenated dNTPs with the corresponding propargyl-glycosides. The nucleotides were found to be good substrates for DNA polymerases in enzymatic primer extension and PCR synthesis of modified and hypermodified DNA displaying up to four different sugars. Proof of concept binding study of sugar-modified oligonucleotides with concanavalin A showed positive effect of avidity and sugar units count.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/GX20-00885X" target="_blank" >GX20-00885X: Novel Functionalized (Bio)polymers Based on DNA Display of Small Molecules</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemistry - A European Journal
ISSN
0947-6539
e-ISSN
1521-3765
Volume of the periodical
30
Issue of the periodical within the volume
48
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
e202402318
UT code for WoS article
001282323500001
EID of the result in the Scopus database
2-s2.0-85200162118